Fundamentals of Statistical Genetics
STA480 (Undergraduate) and STA2080 (Graduate)

Winter 2018



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GENERAL INFORMATION


COURSE SYLLABUS AND LECTURE NOTES

Statistical genetics is an important data science research area with direct impact on population health, and this course provides an INTRODUCTION to its concepts and fundamentals. We start with an overview of genetic studies to have a general understanding of its goal and study design. We then introduce the basic genetic terminologies necessary for the ensuing discussion of the various statistical methods used for analyzing genetic data. The specific topics include population genetics, principles of inheritance, likelihood for pedigree data, aggregation, heritability and segregation analyses, map and linkage analysis, population-based and family-based association studies and genome-wide association studies. The flow of the content generally follows that of the "The Fundamentals of Modern Statistical Genetics" by Laird and Lange, and additional materials will be provided. Participating students do not need formal training in genetics, but they are expected to have statistical knowledge at the level of STA303 - Methods of Data Analysis or equivalent.