The detrimental effects of the winner’s curse are becoming well-recognized in Genome-Wide Association Studies. Br2 implements a bootstrap based bias reduction method, to correct for the effects of Winner's curse in association studies.
To obtain and run br2, download a version suitable for your computer platform. br2 runs on most major platforms (Linux, MacOS, Windows). It is developed in C++ and the source code is freely available in the download page.
See the documentation for instructions on how to use and apply br2 to your dataset.
Documentation on how to install and use br2 on your dataset is available here:
|br2-linux-v1.12.tar.gz||Linux executable v1.12|
|br2-linux-v1.12-openmp.tar.gz||Linux executable v1.12 with multi-CPU support|
|br2-source-v1.12.tar.gz||Source code for version 1.12|
|br2-linux-1.06.tar.gz||Linux executable v1.06|
|br2-linux-1.06-openmp.tar.gz||Linux executable v1.06 with multi-CPU support|
|br2-macos-1.06.zip||MacOS executable v1.06|
|br2-macos-1.06-openmp.zip||MacOS executable v1.06 with multi-CPU support|
|br2-1.06-source.tar.gz||Source code for version 1.06|
Apostolos Dimitromanolakis (apostol<at>cs<dot>toronto<dot>edu)